The draw for the Senior Division Cup competition for 2021/22 is detailed below:
Group A
 | 
| # | 
Team | 
Pld | 
W | 
D | 
L | 
GF | 
GA | 
Pts | 
GD | 
| 1 | 
East Way Athletic | 
3 | 
3 | 
0 | 
0 | 
10 | 
6 | 
9 | 
+4 | 
| 2 | 
Flyhouse Athletic | 
3 | 
2 | 
0 | 
1 | 
12 | 
8 | 
6 | 
+4 | 
| 3 | 
Barking Riverside | 
3 | 
1 | 
0 | 
2 | 
3 | 
11 | 
3 | 
-8 | 
| 4 | 
London Mavericks | 
3 | 
0 | 
0 | 
3 | 
0 | 
0 | 
0 | 
0 | 
Group B
 | 
| # | 
Team | 
Pld | 
W | 
D | 
L | 
GF | 
GA | 
Pts | 
GD | 
| 1 | 
Secret | 
3 | 
3 | 
0 | 
0 | 
11 | 
5 | 
9 | 
+6 | 
| 2 | 
Roose | 
3 | 
2 | 
0 | 
1 | 
8 | 
9 | 
6 | 
-1 | 
| 3 | 
United Dian | 
3 | 
1 | 
0 | 
2 | 
6 | 
9 | 
3 | 
-3 | 
| 4 | 
Belfry | 
3 | 
0 | 
0 | 
3 | 
1 | 
3 | 
0 | 
-2 | 
Group C
 | 
| # | 
Team | 
Pld | 
W | 
D | 
L | 
GF | 
GA | 
Pts | 
GD | 
| 1 | 
El Valiente | 
3 | 
2 | 
1 | 
0 | 
9 | 
5 | 
7 | 
+4 | 
| 2 | 
Hatch Lane | 
3 | 
2 | 
1 | 
0 | 
3 | 
2 | 
7 | 
+1 | 
| 3 | 
Avintul | 
3 | 
1 | 
0 | 
2 | 
5 | 
6 | 
3 | 
-1 | 
| 4 | 
Barking & Dagenham Wanderers | 
3 | 
0 | 
0 | 
3 | 
2 | 
6 | 
0 | 
-4 | 
Group D
 | 
| # | 
Team | 
Pld | 
W | 
D | 
L | 
GF | 
GA | 
Pts | 
GD | 
| 1 | 
Brook Athletic | 
3 | 
3 | 
0 | 
0 | 
4 | 
2 | 
9 | 
+2 | 
| 2 | 
FC Ballr | 
3 | 
2 | 
0 | 
1 | 
2 | 
4 | 
6 | 
-2 | 
| 3 | 
Baiteze Squad | 
3 | 
1 | 
0 | 
2 | 
0 | 
0 | 
3 | 
0 | 
| 4 | 
East Stars | 
3 | 
0 | 
0 | 
3 | 
0 | 
0 | 
0 | 
0 | 
Following group games, sides progress through to Senior Division Cup or Premier Division Cup knock-out depending on finishing position.